Vasculitis & polymyalgia rheumatica
Validation and clinical application of 2022 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria for Takayasu arteritis in a large Chinese cohort
Authors' conclusion
Compared with the 1990 ACR criteria, the 2022 ACR/EULAR criteria for TAK demonstrate better specificity and sensitivity in real-world clinical practice. The score derived from the 2022 classification criteria is related to the prognosis.
Study context
- Population
- Chinese cohort of patients with TAK and patients with non-TAK778 TAK, 378 non-TAK
- Comparison
- 2022 ACR/EULAR vs 1990 ACR classification criteria for TAK
- Outcome
- Sensitivity, specificity, PPV, NPV, accuracy and AUC of the criteria
Methodological detailsvalidation cohort
- Validation cohort
Performance
As reported in the abstract
Classification performance for TAK
| Test or model | AUC | Sensitivity | Specificity |
|---|---|---|---|
| 2022 ACR/EULAR criteria | 0.955 (0.940-0.970) | 95.2% (95% CI: 93.4-96.5%)Sensitivity on a scale from 0 to 100 percent | 95.8% (93.1-97.5%)Specificity on a scale from 0 to 100 percent |
| 1990 ACR criteria | 0.930 (0.911-0.948) | 93.6% (91.6-95.1%)Sensitivity on a scale from 0 to 100 percent | 92.3% (89.0-94.7%)Specificity on a scale from 0 to 100 percent |
AUC
2022 ACR/EULAR criteria0.955 (0.940-0.970)
1990 ACR criteria0.930 (0.911-0.948)
Sensitivity
2022 ACR/EULAR criteria95.2% (95% CI: 93.4-96.5%)
1990 ACR criteria93.6% (91.6-95.1%)
Sensitivity on a scale from 0 to 100 percentSpecificity
2022 ACR/EULAR criteria95.8% (93.1-97.5%)
1990 ACR criteria92.3% (89.0-94.7%)
Specificity on a scale from 0 to 100 percentFurther findings
Misclassified cases (2022 ACR/EULAR criteria)
- False negatives had fewer vascular ischaemia symptoms and less affected arterial regions than true positives; false positives mainly differed in angina and blood pressure
Overall survival by 2022 ACR/EULAR score
- Scores ≥15 had significantly lower overall survival than scores <15
- Kaplan-Meier analysis
Original publication
Validation and clinical application of 2022 ACR/EULAR criteria for Takayasu arteritis in a large Chinese cohort. Rheumatology (Oxford). Published 11 July 2025. doi:10.
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