Vasculitis & polymyalgia rheumatica
PET vascular activity score for predicting new angiographic lesions in patients with Takayasu arteritis: a Chinese cohort study
Main finding · New angiographic lesionsResult — go to the resultHazard ratio 7.56 95% CI 2.20–26.01Authors' conclusion
PETVAS showed good performance in predicting new lesions in Takayasu arteritis.
Study context
- Population
- Chinese patients with newly diagnosed TAK, followed up for at least 2 years
- Participants
- 82 patients
- Exposure
- Baseline PET vascular activity scores (PETVAS) ≥8 vs lower PETVAS
- Outcome
- New angiographic lesions on magnetic resonance angiography
Methodological detailsmultivariate Cox regression
- Multivariate Cox regression
Main finding
New angiographic lesions
Hazard ratio
7.56
95% CI 2.20–26.01
P < 0.01
PETVAS ≥8vs PETVAS <8
HR 7.56 (95% CI 2.20–26.01); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incidence of new lesions (whole cohort) · median follow-up 36 months
- Patients with new lesions
- 18 (22%)
- Median time to first new lesion (months)
- 18
Correlation of PETVAS with ESR and CRP at baseline
- PETVAS vs ESR, r
- 0.74, P < 0.01
- PETVAS vs CRP, r
- 0.69, P < 0.01
Characteristics, without vs with new lesions
- Female (without vs with new lesions)
- 67.2% vs 94.4%, P = 0.03
- ESR (without vs with new lesions)
- 20 vs 49, P = 0.02
- Active disease (without vs with new lesions)
- 62.5% vs 94.4%, P < 0.01
Safety
Adverse events including arterial ischaemic events · during follow-up
- More likely in patients with PETVAS ≥8 at baseline
Original publication
PET vascular activity score for predicting new angiographic lesions in patients with Takayasu arteritis: a Chinese cohort study. Rheumatology (Oxford). Published 6 February 2023. doi:10.
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