Lupus & antiphospholipid syndrome
Urinary congophilia as a predictive biomarker of lupus nephritis in pregnant and non-pregnant women with systemic lupus erythematosus
Authors' conclusion
Urinary congophilia may add a diagnostic value in patients with LN and can be a reliable marker of disease activity. CRR is related to disease activity rather than pregnancy.
Study context
- Population
- Pregnant and non-pregnant women with lupus nephritis (LN) and pregnant healthy controlsrenal biopsy in 33 non-pregnant LN
- Participants
- 45 / 12 / 38
- Comparison
- Urinary congophilia (Congo Red Dot Blot assay) in pregnant and non-pregnant LN women vs pregnant healthy controls
- Non-pregnant LNn = 45
- Pregnant LNn = 12
- Pregnant healthy controlsn = 38reference
- Outcome
- Predictive value of urinary congophilia (Congo red retention, CRR) as a marker of LN activity
Performance
As reported in the abstract
CRR for high LN activity (NIH-AI >10) vs lower activity
Congo red retention (CRR) cut point ≥21.85: sensitivity
83%
CRR cut point ≥21.85: specificity
58%
Further findings
| Outcome | P value |
|---|---|
| CRR values, pregnant LN: active vs inactive and vs healthy controlsPregnant active LN vs Pregnant inactive LN · significantly higher in active | P = 0.014 |
| CRR values, pregnant LN: active vs inactive and vs healthy controlsPregnant active LN vs Pregnant healthy controls · significantly higher in active | P = 0.009 |
| CRR values, non-pregnant LN: active vs inactive and vs healthy controlsNon-pregnant active LN vs Non-pregnant inactive LN · significantly higher in active | P = 0.016 |
| CRR values, non-pregnant LN: active vs inactive and vs healthy controlsNon-pregnant active LN vs Pregnant healthy controls · significantly higher in active | P ≤ 0.001 |
Correlations of CRR with disease markers
- anti-ds-DNA, r (p ≤ .001)
- 0.791
- Serum creatinine, r (p ≤ .001)
- 0.620
- SLE Disease Activity Index (SLEDAI) score, r (p ≤ .001)
- 0.623
- SLEDAI-R score, r (p = .005)
- 0.473
- Serum albumin, r (p = .001)
- −0.454
Original publication
Urinary congophilia as a predictive biomarker of lupus nephritis in pregnant and non-pregnant women with systemic lupus erythematosus. Lupus. Published 3 January 2025. doi:10.
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