Lupus & antiphospholipid syndrome
Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders
Authors' conclusion
Our findings underscore the gut microbiome's critical role in autoimmune diseases, offering insights into shared and distinct microbial signatures.
Study context
- Population
- Metagenomic datasets from patient cohorts with six autoimmune conditions and CRC
- Comparison
- Six autoimmune conditions vs CRC metagenomes
Methodological detailsmetagenomic analysis, protein-protein interaction analyses, experimental validation
- Metagenomic analysis
- Protein-protein interaction analyses
- Experimental validation
Main finding
As reported in the abstract
- Distinct microbial signatures across autoimmune disorders, with notable overlaps between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD)
- Significant predictive biomarkers highlighted diverse microbial influences across conditions
- Protein-protein interactions targeting GC signalling, antigen presentation and IL-12 signalling pathways
- Experimental validation confirmed interactions between host glucocorticoid receptor (NR3C1) and specific gut bacteria-derived proteins
Original publication
Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders. Ann Rheum Dis. Published 2 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →