Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study
Authors' conclusion
Uptake of pneumococcal vaccination in UK patients with IMIDs was suboptimal. Vaccination against pneumococcal disease was not associated with IMID flare.
Study context
- Population
- Adults with immune-mediated inflammatory diseases (IMIDs) diagnosed on or before 1 September 2018, prescribed steroid-sparing drugs within the last 12 months, contributing data to CPRD Gold (UK)
- Participants
- 32,277 adults
- Exposure
- Post-vaccination exposed period vs unexposed periods
- RAn = 14,151
- IBDn = 13,631
- Axial SpAn = 3,804
- SLEn = 691
- Outcome
- Pneumococcal vaccine uptake; association between pneumococcal vaccination and IMID flare
Methodological detailsUK-wide, Clinical Practice Research Datalink Gold, self-controlled case series: 14-day pre-vaccination induction, 90 days post-vaccination exposed, remaining unexposed periods (up to 6 months before and after vaccination)
- UK-wide
- Clinical Practice Research Datalink Gold
- Self-controlled case series: 14-day pre-vaccination induction, 90 days post-vaccination exposed, remaining unexposed periods (up to 6 months before and after vaccination)
Main finding
As reported in the abstract
Pneumococcal vaccine uptake
Overall vaccinated against pneumococcus
57%
Uptake in those younger than 45 years
32%
Uptake with IBD
42%
Uptake without additional indication(s) for vaccination
46%
Observational data: associations, not effects.
Safety
| Outcome | IRR (95% CI) | |
|---|---|---|
| Primary-care consultations for joint pain, exposed period · 90 days post-vaccinationExposed periodvs Unexposed periods1067 vaccinated patients | 0.95 (0.83–1.09) | |
| Primary-care consultations for autoimmune rheumatic disease flare, exposed period · 90 days post-vaccinationExposed periodvs Unexposed periods935 vaccinated patients | 1.05 (0.92–1.19) | |
| Primary-care consultations for IBD flare, exposed period · 90 days post-vaccinationExposed periodvs Unexposed periods451 vaccinated patients | 0.83 (0.65–1.06) | |
| 0.512Incidence rate ratio (log scale) |
Original publication
Uptake and safety of pneumococcal vaccination in adults with immune-mediated inflammatory diseases: a UK wide observational study. Rheumatology (Oxford). Published 13 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →