Association between SARS-CoV-2 booster vaccination and hospitalisation and/or death due to COVID-19 in adults with immune-mediated inflammatory diseases: nested case–control study using linked primary-care, hospitalisation and mortality data from England
Authors' conclusion
COVID-19 booster vaccination was associated with fewer hospitalisation and/or death due to COVID-19 among adults with IMIDs.
Study context
- Population
- Adults with immune-mediated inflammatory diseases (IMIDs) prescribed steroid-sparing immune-suppressing drugs in Clinical Practice Research Datalink Aurum, England (mean age 65.5 years; 60.2% women)2,178 cases · 17,750 controls
- Comparison
- COVID-19 booster vaccination vs no booster
- Outcome
- Hospitalisation and/or death due to COVID-19
Methodological detailsrisk-set matched controls, multivariable logistic regression, linked primary-care, hospitalisation and mortality data
- Risk-set matched controls
- Multivariable logistic regression
- Linked primary-care, hospitalisation and mortality data
Main finding
As reported in the abstract
Hospitalisation and/or death due to COVID-19, by number of boosters
Each group vs no boosterAdjusted odds ratio (95% CI)
Three boosters
0.20(0.15–0.28)
Two boosters
0.29(0.23–0.36)
One booster
0.56(0.48–0.65)
Further findings
Hospitalisation and/or death due to COVID-19, by booster cycle
| aOR (95% CI) | ||
|---|---|---|
| Autumn 2021 booster | 0.40 (0.32–0.50) | |
| Spring 2022 booster | 0.52 (0.42–0.65) | |
| Autumn 2022 booster | 0.33 (0.25–0.43) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Hospitalisation and/or death due to COVID-19, by time since last booster
- Negatively associated with booster within 365 days vs no booster
- No statistically significant association for boosters received more than 365 days ago
Original publication
Association between SARS-CoV-2 booster vaccination and hospitalisation and/or death due to COVID-19 in adults with immune-mediated inflammatory diseases: nested case–control study using linked primary-care, hospitalisation and mortality data from England. RMD Open. Published 3 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →