Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients With Rheumatoid Arthritis
Authors' conclusion
There is a positive correlation between the complement system and MetS among nondiabetic patients with RA. This association is independent of traditional IR factors.
Study context
- Population
- Nondiabetic patients with rheumatoid arthritis (RA)
- Participants
- 339 patients
- Outcome
- Relationship between a comprehensive evaluation of the complement system (functional assays of the 3 pathways and serum levels of individual components) and IR (homeostatic model assessment) and MetS
Methodological detailsmultivariable linear regression analysis
- Multivariable linear regression analysis
Main finding
As reported in the abstract
- Many elements of the upstream and common complement pathways, but not the functional tests of the 3 routes, correlated positively with higher insulin resistance (IR) and β cell function
- After multivariable adjustment for factors associated with IR, these relationships were lost
- Metabolic syndrome (MetS) maintained a relationship with higher levels of C1q, C4, C3, properdin and factor I after adjusting for confounders
Observational data: associations, not effects.
Original publication
Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients With Rheumatoid Arthritis. J Rheumatol. Published 1 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →