The Fibrosis-4 Index (FIB-4) correlates with cardiovascular risk and insulin resistance in patients with rheumatoid arthritis
Authors' conclusion
Up to 20% of RA patients show an abnormal FIB-4 index, which correlates with cardiovascular risk and insulin resistance.
Study context
- Population
- Patients with rheumatoid arthritis (RA)
- Participants
- 465 patients
- Exposure
- Low vs Indeterminate vs High
- Outcome
- FIB-4 index and its association with disease characteristics and cardiovascular (CV) comorbidities (lipid profile, subclinical carotid atherosclerosis, insulin resistance indices)
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
FIB-4 indicating indeterminate or high risk for hepatic fibrosis
RA patients with indeterminate or high FIB-4
20%
Observational data: associations, not effects.
Original publication
The Fibrosis-4 Index (FIB-4) correlates with cardiovascular risk and insulin resistance in patients with rheumatoid arthritis. Rheumatology (Oxford). Published 21 May 2025. doi:10.
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