Clinical and serological associations of interferon-α and interferon-γ in rheumatoid arthritis patients
Authors' conclusion
Serum levels of IFN-α, but not IFN-γ, are associated with disease activity in patients with RA. However, neither IFN is correlated with the cardiovascular comorbidities commonly observed in this population.
Study context
- Population
- Patients with rheumatoid arthritis (RA); associations of serum IFN-α and IFN-γ (Simoa) with disease characteristics and cardiovascular comorbidity (lipids, insulin resistance, metabolic syndrome, carotid US)
- Participants
- 216 patients
- Outcome
- Associations between serum IFN-α and IFN-γ and RA disease manifestations, with special attention to cardiovascular involvement
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
- Serum IFN-α and IFN-γ significantly correlated with each other and associated with circulating IL-2, IL-6 and IL-8
- After multivariable adjustment, higher serum IFN-α positively associated with RF and ACPA positivity and with increased disease activity scores
- IFN-γ showed no significant associations with most clinical manifestations of RA
- Neither IFN-α nor IFN-γ related to cardiovascular comorbidities, incl. lipid profiles, insulin resistance indices or carotid US findings
Observational data: associations, not effects.
Original publication
Clinical and serological associations of interferon-α and interferon-γ in rheumatoid arthritis patients. Rheumatology (Oxford). Published 29 January 2026. doi:10.
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