Ultrasonography in the prediction of gout flares: a 12-month prospective observational study
Authors' conclusion
Baseline US findings indicating MSU deposits and US-detected inflammation are independent predictors of gout flares over 12 months.
Study context
- Population
- Gout patients on ULT for at least the preceding 6 months, enrolled consecutively71 completed
- Participants
- 81 patients
- Exposure
- Cases vs controls: baseline US findings
- Casesn = 30
- Outcome
- Gout flares predicted by baseline US findings of MSU deposits and power Doppler signal
- Follow-up
- 12 months
Methodological detailssingle-centre, nested case-control analysis, multivariate analyses
- Single-centre
- Nested case-control analysis
- Multivariate analyses
Main finding
As reported in the abstract
Baseline US scores and flare occurrence and number (multivariate)
Estimate (95% CI)
Total MSU score
aOR (flare occurrence) 1.75(1.26–2.43)
Power Doppler score
aOR (flare occurrence) 1.63(1.12–2.40)
Total MSU score
adjusted IRR (number of flares) 1.17(1.08–1.26)
Power Doppler score
adjusted IRR (number of flares) 1.29(1.19–1.40)
Observational data: associations, not effects.
Further findings
| Outcome | Cases | Controls | P value |
|---|---|---|---|
| Participants with ≥1 flare · 12 months | 42.3% | — not stated in the abstract | |
| Baseline US burden of MSU deposits | 6.7 ± 4.7 | 2.9 ± 2.6 | P = 0.01 |
| Baseline power Doppler signal | 3.73 ± 3.53 | 0.82 ± 1.44 | P < 0.01 |
— not stated in the abstract
- Participants with ≥1 flare — Median number of flares
- 2.0
- Participants with ≥1 flare: of 71 participants
Original publication
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study. Rheumatology (Oxford). Published 3 August 2022. doi:10.
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