Gout Flares After Stopping Anti‐Inflammatory Prophylaxis: A Rapid Literature Review and Meta‐Analysis
Pooled result · Participants with ≥1 gout flare (pooled random effects estimate)Result — go to the resultMean difference 16.0%Authors' conclusion
Gout flares are common after stopping anti-inflammatory prophylaxis but return to levels seen during prophylaxis.
Study context
- Population
- Clinical trials of people with gout with at least one arm starting or intensifying urate-lowering therapy (ULT) with coprescription of anti-inflammatory prophylaxis; PubMed from inception to February 20246 trials + VA STOP Gout
- Participants
- 2,972 participants
- Comparison
- Gout flares during anti-inflammatory prophylaxis vs after ceasing prophylaxis
- Outcome
- Percentage of participants experiencing one or more gout flares in each period
Methodological detailsrandom effects meta-analysis, includes aggregated, unpublished VA STOP Gout trial data
- Random effects meta-analysis
- Includes aggregated, unpublished VA STOP Gout trial data
Pooled result
As reported in the abstract
Participants with ≥1 gout flare (pooled random effects estimate)
Mean difference
16.0%
P < 0.001
By group
Further pooled results
Sensitivity analyses
- No material effects of prophylaxis duration, trial duration, ULT class, or placebo arms
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Gout Flares After Stopping Anti‐Inflammatory Prophylaxis: A Rapid Literature Review and Meta‐Analysis. Arthritis Care Res (Hoboken). Published 1 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →