Lupus & antiphospholipid syndrome
U-KIM-1 as a predictor of treatment response in lupus nephritis
Authors' conclusion
These data suggest that u-KIM-1 levels correlate with LN disease activity and renal histopathology findings and may be used as a predictor of treatment response.
Study context
- Population
- SLE patients38 active lupus nephritis (LN) biopsied
- Participants
- 61 patients
- Comparison
- Active LN vs inactive LN; higher vs lower baseline u-KIM-1
- Active LNn = 38
- Outcome
- u-KIM-1 levels and LN activity, histology and renal function
Methodological detailsU-KIM-1 measured by ELISA
- U-KIM-1 measured by ELISA
Main finding
As reported in the abstract
- Proteinuria and u-KIM-1 levels elevated in active LN vs inactive LN
- U-KIM-1 and proteinuria decreased with intensified treatment
- U-KIM-1 levels correlated with % glomerular crescent formation in renal pathology
- Higher baseline u-KIM-1: significantly higher eGFR and lower LN disease activity at 12 months after treatment intensification
Original publication
U-KIM-1 as a predictor of treatment response in lupus nephritis. Lupus. Published 28 October 2022. doi:10.
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