Lupus & antiphospholipid syndrome
Factors associated with poor outcomes in systemic lupus erythematosus (SLE) patients with COVID-19: Data from ReumaCoV-Brazil register
Authors' conclusion
Hypertension and cyclophosphamide were associated with a severe outcome, and telemedicine can be a useful tool for SLE patients with COVID-19.
Study context
- Population
- Adult SLE patients in the ReumaCoV Brazil register during the SARS-CoV-2 pandemic
- Participants
- 604 patients
- Exposure
- SLE patients with COVID-19 vs SLE patients without COVID-19
- COVID-19n = 317
- Controln = 287reference
- Outcome
- Factors associated with COVID-19 severity outcomes (hospitalization related to COVID-19)
Methodological detailsprospective, multi-stage cohort
- Prospective, multi-stage cohort
Main finding
As reported in the abstract
Factors independently associated with hospitalization related to COVID-19
Odds ratio (95% CI)P value
Arterial hypertension
2.48(1.04–5.91)
P = 0.041Cyclophosphamide
14.32(2.12–96.77)
P = 0.006Dyspnea
7.10(3.10–16.23)
P < 0.001Telemedicine support67% lower chance of hospitalization
0.33(0.12–0.88)
P = 0.02- Discontinuation of SLE treatment during infection
- 5.38 (95% CI 1.97–15.48); P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | COVID-19 | Control | P value |
|---|---|---|---|
| SLEDAI-2K score, post-COVID-19 periodNo difference between groups | mean 5.8 (unspecified (bracketed) 8.6) | mean 4.5 (unspecified (bracketed) 8.0) | P = 0.190 |
| SLE activity by PGA, post-COVID-19 periodInfected patients reported increased SLE activity | 2.9 (unspecified (bracketed) 2.9) | — withheld: not confirmed against the abstract | P = 0.031 |
— withheld: the automatic checks could not confirm the value against the abstract
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Factors associated with poor outcomes in SLE patients with COVID-19: Data from ReumaCoV-Brazil register. Lupus. Published 27 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →