Lupus & antiphospholipid syndrome
The adjusted Global Anti-Phospholipid Syndrome Score as predictor of damage accrual measured by Damage Index for APS: a longitudinal study
Authors' conclusion
Our data support the utility of longitudinal assessing of the aGAPSS score in predicting damage accrual, measured by DIAPS, in APS.
Study context
- Population
- Patients with thrombotic and non-thrombotic APS (138 primary, 62 associated with other autoimmune diseases)138 primary, 62 associated APS
- Participants
- 200 patients
- Exposure
- High vs low damage accrual
- Outcome
- Association between mean aGAPSS over time and change in DIAPS during follow-up
- Follow-up
- Up to 6 years (minimum 3 years)
Methodological detailslinear regression models, multivariate analysis
- Linear regression models
- Multivariate analysis
Main finding
As reported in the abstract
Mean aGAPSS and DIAPS change (multivariate linear regression)
Higher mean adjusted' Global APS Score (aGAPSS) associated with Damage Index for APS (DIAPS) increase during follow-up, b
0.04
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Odds of DIAPS increment ≥1 point per aGAPSS | 1.12 (1.04–1.21) | P = 0.003 | |
| 0.512Odds ratio (log scale) |
Mean
| Outcome | High damage accrual | Low damage accrual | P value |
|---|---|---|---|
| Mean aGAPSS by damage accrual | 9.22 (95% CI 7.58–10.86) | 6.72 (95% CI 6.0–7.43) | P = 0.003 |
Original publication
The adjusted Global Anti-Phospholipid Syndrome Score as predictor of damage accrual measured by Damage Index for APS: a longitudinal study. Rheumatology (Oxford). Published 25 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →