Trends and outcomes of lung transplant listings for connective tissue disease-associated interstitial lung disease (CTD-ILD): A 20-Year analysis from the organ procurement and transplantation network database
Authors' conclusion
Over two decades, CTD-ILD transplant listings have increased in volume, matched with substantially improved outcomes.
Study context
- Population
- Adults ≥18 years with CTD-ILD listed for lung transplantation, Organ Procurement and Transplantation Network (OPTN) database, 2003–2023
- Participants
- 1,977 listed CTD-ILD patients
- Exposure
- Trends across four time periods and across six CTD diagnoses
- Outcome
- Lung transplant listing trends and outcomes; factors associated with undergoing lung transplantation
Methodological detailsnational registry (OPTN), univariate and multivariable logistic regression
- National registry (OPTN)
- Univariate and multivariable logistic regression
Main finding
As reported in the abstract
Lung transplant listings over time
Listings increased fourfold from the first to last time periods
185 to 744
Scleroderma constituted the majority of listings
47%
Observational data: associations, not effects.
Further findings
Factors associated with undergoing lung transplantation
- Older age, lower lung allocation scores and male sex associated with higher odds of transplantation; female sex with lower odds
Original publication
Trends and outcomes of lung transplant listings for connective tissue disease-associated interstitial lung disease (CTD-ILD): A 20-Year analysis from the organ procurement and transplantation network database. Semin Arthritis Rheum. Published 12 March 2026. doi:10.
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