Long-term evaluation of pulmonary function and survival of patients with interstitial pneumonia with autoimmune features
Authors' conclusion
Long-term pulmonary function and six-minute walk test remained stable over 36 months in our IPAF cohort. Prognosis and pulmonary function in UIP had similar outcomes compared to non-UIP.
Study context
- Population
- Patients fulfilling interstitial pneumonia with autoimmune features (IPAF) criteria35 sub-classified into connective tissue disease (CTD)-like subgroups
- Participants
- 59 patients
- Exposure
- CTD-like subgroups and usual interstitial pneumonia (UIP) vs non-UIP radiologic patterns
- Outcome
- Change in FVC%, DLCO% and six-minute walk distance over time, and survival
Methodological detailslinear mixed-effect models
- Linear mixed-effect models
Main finding
As reported in the abstract
FVC%, DLCO% and six-minute walk distance over time
- FVC%, DLCO%, and six-minute walk distance (SMWD) remained stable over time
- No difference between UIP vs non-UIP radiologic patterns
Observational data: associations, not effects.
Further findings
Survival, entire cohort · 60 and 120 months
- Survival at 60 months
- 79%
- Survival at 120 months
- 53%
- Survival similar among CTD-like subgroups and radiological patterns
Original publication
Long-term evaluation of pulmonary function and survival of patients with interstitial pneumonia with autoimmune features. Clin Exp Rheumatol. Published 28 November 2021. doi:10.
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