Systemic sclerosis & Raynaud's
Trends in adverse pregnancy outcomes among women with systemic sclerosis in the United States
Authors' conclusion
In this large nationwide sample, the risk of fetal death among women with SSc markedly improved over the past 18 years. The risk for other APOs remained high in SSc deliveries compared to non-SSc deliveries
Study context
- Population
- Delivery-associated hospitalizations in the United States, National Inpatient Sample 2000–2017
- Participants
- 3,740 SSc delivery hospitalizations
- Exposure
- SSc deliveries vs matched non-SSc deliveries
- SScn = 3,740
- Outcome
- Temporal trends in adverse pregnancy outcomes:
- Maternal and fetal death
- Cesarean delivery
- LOS
- Preterm delivery
- Intrauterine growth restriction
- Hypertensive disorders of pregnancy
Methodological detailsNational Inpatient Sample (NIS) database, 2000 - 2017, each SSc delivery matched to 100 non-SSc deliveries by age, delivery year, and race, multivariable regression with SSc × year interaction term
- National Inpatient Sample (NIS) database, 2000 - 2017
- Each SSc delivery matched to 100 non-SSc deliveries by age, delivery year, and race
- Multivariable regression with SSc × year interaction term
Main finding
As reported in the abstract
Temporal trends in APOs, SSc vs non-SSc · 2000 - 2017
Fetal death in SSc deliveries, 2000 - 2005 (per 1000 delivery-related admissions)
49.0
Fetal death in SSc deliveries, 2012 - 2017 (per 1000 delivery-related admissions)
16.2
Observational data: associations, not effects.
Further findings
- SSc associated with an increased risk of all adverse pregnancy outcomes (APOs) vs non-SSc deliveries
Original publication
Trends in adverse pregnancy outcomes among women with systemic sclerosis in the United States. Semin Arthritis Rheum. Published 22 August 2023. doi:10.
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