Systemic sclerosis & Raynaud's
Epidemiology, outcomes, and expenditures of hospitalized patients with systemic sclerosis: Insights from the U.S. National Inpatient Sample
Authors' conclusion
The inpatient prevalence of SSc exceeds its general population prevalence, indicating a high need for hospital-level care. Hospitalizations among patients with SSc are associated with worse clinical outcomes and significantly greater healthcare expenditures.
Study context
- Population
- Adult hospitalized patients with systemic sclerosis (SSc), 2021 U.S. National Inpatient Sample (over 4000 non-federal acute care hospitals)
- Exposure
- SSc hospitalizations vs matched non-SSc admissions
- Outcome
- Inpatient prevalence of SSc
Methodological detailsmatched comparator group, multivariable analyses, Multivariable analyses adjusted for age, sex, race/ethnicity, Charlson Comorbidity Index, payer type, median income, and hospital characteristics
- Matched comparator group
- Multivariable analyses
- Multivariable analyses adjusted for age, sex, race/ethnicity, Charlson Comorbidity Index, payer type, median income, and hospital characteristics
Main finding
As reported in the abstract
SSc
86.7 per 100,000 admissions
Observational data: associations, not effects.
Further findings
| Outcome | Mean difference (days) (95% CI) | |
|---|---|---|
| LOS | 0.7 (0.5–0.9) | |
| −0.500.51Difference, days (linear scale) |
| Outcome | aOR (95% CI) | |
|---|---|---|
| In-hospital mortality | 1.42 (1.26–1.61) | |
| Shock | 1.30 (1.17–1.44) | |
| Systemic inflammatory response syndrome | 1.32 (1.01–1.74) | |
| Acute respiratory distress syndrome | 1.45 (1.12–1.87) | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | Adjusted mean increase (95% CI) |
|---|---|
| Hospital costs (adjusted mean increase) | $3277 ($2051-$4504) |
| Total charges (adjusted mean increase) | $11,801 ($6485-$17,116) |
- Most common primary diagnoses among SSc hospitalizations
- 22.7% · Sepsis · Heart failure with hypertension 14.4% · COVID-19 11.5%
Comorbid conditions
- SSc had significantly higher odds of several comorbid conditions, including pulmonary hypertension, ILD, osteoporosis, Sjögren's syndrome, and hypertension
Original publication
Epidemiology, outcomes, and expenditures of hospitalized patients with systemic sclerosis: Insights from the U.S. National Inpatient Sample. Joint Bone Spine. Published 30 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →