Time-varying risks of infection in patients as they proceed through the phases of ‘pre-RA’: results from the Scottish Early RA inception cohort
Main finding · Infection (antibiotic prescriptions), 0-6 months prior to symptom onsetResult — go to the resultIncidence rate ratio 1.28 95% CI 1.15–1.42Authors' conclusion
Antibiotic risk is increased in patients with 'pre-RA' at least 6 months before symptoms develop, and this persists throughout the symptomatic pre-RA phase.
Study context
- Population
- Scottish Early RA inception cohort: patients with newly diagnosed RA
- Exposure
- Patients with newly diagnosed RA vs age- and sex-matched controls
- Outcome
- Incidence of infection (community antibiotic prescriptions) during sequential pre-RA and early arthritis phases
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Infection (antibiotic prescriptions), 0-6 months prior to symptom onset
Incidence rate ratio
1.28
95% CI 1.15–1.42
RAvs Controls
IRR 1.28 (95% CI 1.15–1.42)
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| Infection (antibiotic prescriptions), symptomatic pre-RAPersisted into 'early arthritis' | 1.33 (1.18–1.49) | |
| Hospital admissions (serious infections)Early arthritis | 1.82 (1.32–2.46) | |
| 0.512Incidence rate ratio (log scale) |
Hospital admissions (serious infections)
- Numerically greater in 'pre-RA'
Original publication
Time-varying risks of infection in patients as they proceed through the phases of ‘pre-RA’: results from the Scottish Early RA inception cohort. RMD Open. Published 23 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →