Group 3 innate lymphoid cells promotes Th17 cells differentiation in rheumatoid arthritis
Authors' conclusion
ILC3s positively correlated with Th1 and Th17 cells in RA. In CIA, the frequencies of ILC3s changed with disease development and showed a positive correlation with Th1 and Th17 cells. ILC3s may facilitate the differentiation of Th17 cells through direct cell-cell contact.
Study context
- Population
- Rheumatoid arthritis (RA) patients with varying disease activity, healthy controls, and collagen-induced arthritis (CIA) mice
- Comparison
- RA patients vs healthy controls; ILCs (ILC3s) co-cultured directly vs through a transwell insert with naive CD4+ T cells
- Outcome
- ILC subsets and their correlation with Th cells
Methodological detailshuman cross-sectional analysis, CIA mouse model, in vitro co-culture
- Human cross-sectional analysis
- CIA mouse model
- In vitro co-culture
Main finding
As reported in the abstract
- Innate lymphoid cell (ILCs) less frequent in RA than healthy controls, with higher ILC3s in RA
- p<0.05
- ILC3s correlated positively with Th1 and Th17 cells in RA peripheral blood
- p<0.05
- CIA: ILC3s correlated positively with Th1 and Th17 cells in spleen and lymph nodes
- p<0.05
- CIA: splenic NKp46+ ILC3s correlated positively with Th1 and Th17 cells
- p<0.05
Original publication
Group 3 innate lymphoid cells promotes Th17 cells differentiation in rheumatoid arthritis. Clin Exp Rheumatol. Published 30 January 2024. doi:10.
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