Treatment response in rheumatoid arthritis is predicted by the microbiome: a large observational study in UK DMARD-naive patients
Authors' conclusion
DMARDs appear to restore a perturbed microbiome to a eubiotic state. Moreover, microbiome status can be used to predict likelihood of patient response to DMARD.
Study context
- Population
- DMARD-naive, newly diagnosed rheumatoid arthritis (RA) patients during introduction of DMARD treatment, UKat baseline
- Participants
- 144 participants
- Outcome
- Association of stool and saliva microbiome signals with, and prediction of, response to DMARD treatment (minimal clinically important improvement)
Methodological detailsmulticentre, longitudinal, observational, shotgun sequencing of stool and saliva microbiome, Samples collected: n = 365 stool, n = 365 saliva; clinical data at baseline, 6 and 12 weeks
- Multicentre
- Longitudinal
- Observational
- Shotgun sequencing of stool and saliva microbiome
- Samples collected: n = 365 stool, n = 365 saliva; clinical data at baseline, 6 and 12 weeks
Main finding
As reported in the abstract
Stool microbes associated with minimal clinically important improvement
- Stool microbes decreasing in those with minimal clinically important improvement
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Observational data: associations, not effects.
Original publication
Treatment response in rheumatoid arthritis is predicted by the microbiome: a large observational study in UK DMARD-naive patients. Rheumatology (Oxford). Published 30 January 2024. doi:10.
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