Risk and predictors of fractures in early rheumatoid arthritis – A long term follow up study of an inception cohort
Main finding · FracturesResult — go to the resultFully adjusted HR 1.52 95 % CI 1.13–2.06Authors' conclusion
Patients with RA had higher risk of fractures than controls. Fracture risk was related to BMD at baseline and over time in patients with RA. In addition, worse disability (measured by HAQ) over time was associated with higher risk of fractures.
Study context
- Population
- Patients with newly diagnosed rheumatoid arthritis (RA) (164 women/69 men, recruited 1995–2005), followed with clinical assessments and bone mineral density (BMD) from diagnosis to 10 years; fractures through 2019164 women/69 men
- Participants
- 233 patients
- Exposure
- Early RA vs matched population controls
- RAn = 233
- Outcome
- Risk of fractures (identified based on ICD codes)
- Follow-up
- Through 2019
Methodological detailsmatched population controls, Cox regression, long-term follow-up
- Matched population controls
- Cox regression
- Long-term follow-up
Main finding
Fractures
Fully adjusted HR
1.52
95 % CI 1.13–2.06
RAvs Controls
fully adjusted HR 1.52 (95 % CI 1.13–2.06)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Age-sex-adjusted HR (per SD) (95 % CI) | |
|---|---|---|
| Worse disability (higher HAQ scores) over time and fractures, within the RA cohort | 1.33 (1.09–1.63) | |
| 0.512Age-sex-adjusted HR (log scale) |
Baseline predictors of fractures within the RA cohort (multivariate analyses)
- High age, low BMI and low BMD were significant baseline predictors of future fractures
- Baseline RA disease characteristics were not significant predictors
BMD Z-scores over time and fractures, within the RA cohort
- Inverse association between BMD Z-scores over time and fractures
Original publication
Risk and predictors of fractures in early rheumatoid arthritis – A long term follow up study of an inception cohort. Semin Arthritis Rheum. Published 27 June 2024. doi:10.
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