Association between Life's Essential 8 and all-cause or cardiovascular-specific mortality in patients with rheumatoid arthritis
Authors' conclusion
CVH measured by the LE8 score is a robust and independent predictor of all-cause mortality among U.S. RA patients.
Study context
- Population
- Rheumatoid arthritis (RA) patients from NHANES 2005–2018 with linked mortality data through December 31, 2019 (weighted mean age 57.87 years; 58.94% female)median follow-up 82 months
- Participants
- 1,424 patients
- Exposure
- Moderate- and low-CVH vs high-CVH
- Outcome
- All-cause and CVD mortality
Methodological detailsweighted multivariable Cox regression, logistic regression, restricted cubic spline models
- Weighted multivariable Cox regression
- Logistic regression
- Restricted cubic spline models
Main finding
As reported in the abstract
All-cause mortality
Moderate-CVH vs High-CVH: increased risk of all-cause mortality
85.8%
Low-CVH vs High-CVH: increased risk of all-cause mortality
129.5%
Deaths recorded (all-cause)
270
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) mortality per 1 point decrease in LE8 score (adjusted)
- Increased risk of CVD mortality per 1 point LE8 decrease
- 2.6%
- CVD deaths recorded
- 85
- After adjustment for potential confounders
All-cause mortality by subgroup
- Significant interactions between LE8 score and non-Hispanic white population with risk of all-cause mortality
Sensitivity analysis
- Results robust for all-cause mortality, but not for CVD mortality
Original publication
Association between Life's Essential 8 and all-cause or cardiovascular-specific mortality in patients with rheumatoid arthritis. Clin Exp Rheumatol. Published 23 November 2023. doi:10.
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