Correlation of Naples prognostic score with the risk of all-cause and cardiovascular mortality in individuals with rheumatoid arthritis: A cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2001–2018
Main finding · All-cause mortalityResult — go to the resultHazard ratio 2.04 95% CI 1.21–3.05Authors' conclusion
In the US population, NPS shows a significantly positive correlation with the likelihood of all-cause and CV mortality in individuals with RA.
Study context
- Population
- Individuals with RA in NHANES 2001–2018, US
- Participants
- 1,683 individuals
- Exposure
- Naples Prognostic Score (NPS) Group 3 vs Group 1
- Outcome
- All-cause and CV mortality
Methodological detailsweighted multivariate Cox regression, Kaplan-Meier survival analysis, subgroup and sensitivity analyses
- Weighted multivariate Cox regression
- Kaplan-Meier survival analysis
- Subgroup and sensitivity analyses
Main finding
All-cause mortality
Hazard ratio
2.04
95% CI 1.21–3.05
P < 0.01
Group 3vs Group 1
HR 2.04 (95% CI 1.21–3.05); P < 0.01
As reported in the abstract
- Notable survival discrepancies among NPS groups in all-cause and cardiovascular (CV) mortality (Kaplan-Meier)
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CV mortalityAdjusted for all confounders | 3.59 (1.24–10.4) | P < 0.05 | |
| 0.050.21520Hazard ratio (log scale) |
Subgroup and sensitivity analyses
- Results were robust
Original publication
Correlation of Naples prognostic score with the risk of all-cause and cardiovascular mortality in individuals with rheumatoid arthritis: A cross-sectional analysis of the NHANES 2001–2018. Joint Bone Spine. Published 26 May 2025. doi:10.
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