Performance of the new PREVENT score for indicating subclinical atherosclerosis in rheumatoid arthritis
Authors' conclusion
The newly updated PREVENT scores are not better than the prior PCE for indicating subclinical coronary and carotid atherosclerosis in RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA) without known CVD who underwent chest CT (coronary artery calcium (CAC) score) and carotid artery US (carotid plaque)
- Comparison
- Pooled Cohort Equations (PCE) vs PREVENT scores (Total CVD, atherosclerotic cardiovascular disease (ASCVD), Total CVD + urine albumin-to-creatinine ratio (uACR)) for indicating subclinical coronary and carotid atherosclerosis
- Outcome
- Performance (AUROC) in indicating CAC >0 and presence of carotid plaque
Performance
As reported in the abstract
CAC >0
| Test or model | AUROC |
|---|---|
| PREVENT ASCVD | 0.723 |
| PCE | 0.775 |
AUROC
PREVENT ASCVD0.723
PCE0.775
- PREVENT ASCVD vs PCE: P = 0.034 — PREVENT ASCVD lower than PCE
Further findings
| Outcome | P value |
|---|---|
| PCE vs each PREVENT score (score values)Significantly different from each PREVENT score | P < 0.001 |
Carotid plaque
- No difference in AUROC between PCE and PREVENT ASCVD, PREVENT Total CVD or PREVENT Total CVD + uACR
PCE vs each PREVENT score (score values)
- PCE and PREVENT scores significantly associated with all levels of CAC and carotid plaque
Original publication
Performance of the new PREVENT score for indicating subclinical atherosclerosis in rheumatoid arthritis. Rheumatology (Oxford). Published 24 May 2025. doi:10.
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