Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA ‐Brasil
Authors' conclusion
In this cohort, RA was associated with CAC progression despite no association with prevalence or incidence.
Study context
- Population
- Adults without prior CVD in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil); mean ± SD age 51.5 ± 8.9 years; 55.5% female86 rheumatoid arthritis (RA), 499 controls
- Participants
- 585 adults
- Exposure
- RA vs controls
- RAn = 86
- Controlsn = 499reference
- Outcome
- Coronary artery calcium (CAC) prevalence, incidence and progression (Berry criteria), CAC by CT (Agatston method)
- Follow-up
- Four years
Methodological detailsmultivariable regression, hierarchically adjusted, nonparametric bootstrap confidence intervals (CIs) for progression
- Multivariable regression, hierarchically adjusted
- Nonparametric bootstrap CIs for progression
Main finding
As reported in the abstract
CAC prevalence, incidence and progression
RA vs ControlsEstimate (95% CI)
CAC prevalence, incidence and progression
OR (CAC prevalence, adjusted) 1.34(0.69–2.55)
CAC prevalence, incidence and progression
OR (CAC incidence, adjusted) 0.83(0.05–3.08)
Bootstrap CI
OR (CAC progression, Model 1) 3.11(1.52–8.41)
Bootstrap CI
OR (CAC progression, Model 2) 4.29(1.98–14.65)
Observational data: associations, not effects.
Original publication
Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA ‐Brasil. Arthritis Care Res (Hoboken). Published 11 May 2026. doi:10.
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