Spondyloarthritis & psoriatic arthritis
Tight Control and Radiological Progression: The Radiographic Outcomes of the Tight Control of Psoriatic Arthritis (TICOPA) Study
An erratum to this article was published (J Rheumatol, 1 May 2025 ↗)
Primary result · Change in total mSvdH scoreResult — go to the resultDifference 0.0 95% CI 0.0–0.0Authors' conclusion
These data confirm the benefit of achieving low disease activity states on subsequent radiographic outcomes but did not show a significant impact related to a TC management approach.
Study context
- Population
- Patients with early treatment-naïve psoriatic arthritis (PsA) in the TICOPA trial169 with paired radiographs
- Participants
- 206 patients
- Comparison
- Tight control vs standard care
- TCn = 84
- StdCn = 85reference
- Primary endpoint
- Change in total mSvdH score (hands and feet radiographs)
- Follow-up
- Week 48
Methodological detailsbootstrapped quantile regression adjusting for baseline values and minimization factors, blinded assessor
- Bootstrapped quantile regression adjusting for baseline values and minimization factors
- Blinded assessor
Primary result
Change in total mSvdH score
Difference
0.0
95% CI 0.0–0.0
Change by group
TC
0.0
median · IQR −2.0–0.5
StdC
0.0
median · IQR −2.0–0.0
As reported in the abstract
Further findings
Radiographic progression (increase in total erosion score ≥ 2) · week 48
Radiographic progression (increase in total erosion score ≥ 2) · week 48
- Numerically lower in the TC group
Total mSvdH score change by disease activity state
- Median change lower in those achieving MDA, DAPSA remission and very low disease activity
Characteristics of patients with radiographic progression
- Polyarticular disease and high CRP at presentation; poorer clinical outcomes at weeks 12 and 24
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →