Three‐Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular Juvenile Idiopathic Arthritis (JIA) Consensus Treatment Plans Study
Authors' conclusion
EC was superior to SU across three years for outcomes reflecting time spent in lower disease activity. Starting bDMARD within two months predicted rapid improvement and maintenance of inactive disease.
Study context
- Population
- STOP-JIA participants with polyarticular JIA and Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry follow-up through three years
- Participants
- 297 participants
- Exposure
- Step-up vs early combination vs biologic first treatment plans in polyarticular JIA
- SUn = 190reference
- ECn = 76
- Biologic firstn = 31
- Outcome
- ACR clinically inactive disease (CID) off GC
- Follow-up
- Three-year visit
Methodological detailsconsensus treatment plans, CARRA Registry follow-up, latent class trajectory modeling
- Consensus treatment plans
- CARRA Registry follow-up
- Latent class trajectory modeling
Main finding
As reported in the abstract
P = 0.35 for SU versus EC
Observational data: associations, not effects.
Further findings
| Outcome | SU | EC | P value |
|---|---|---|---|
| Clinical remission on medication (CRM)EC vs SU | 40.6% | 59.9% | P = 0.012 |
| Time spent in CIDEC vs SU | 30% | 38% | P = 0.04 |
| cJADAS-10-ID (cJADAS-10 ≤ 2.5)EC vs SU | 41% | 51% | P = 0.02 |
Rapid improvement trajectory (latent class trajectory modeling (LCTM)) by timing of biologic disease-modifying antirheumatic drug (bDMARD) initiation
- bDMARD initiation within first month from baseline, OR
- 5.33
- bDMARD initiation within second month from baseline, OR
- 2.67
- Slow, moderate and rapid improvement trajectories identified
Original publication
Three‐Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular JIA Consensus Treatment Plans Study. Arthritis Rheumatol. Published 7 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →