Childhood‐Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐Term Kidney Status and Variation in Care
Authors' conclusion
In this cohort with predominately class III/IV nephritis, male sex and older age at cSLE diagnosis were associated with abnormal short-term kidney status. We also observed substantial variation in contemporary medication use for pediatric lupus nephritis between pediatric rheumatology centers.
Study context
- Population
- North American patients with cSLE and kidney biopsy-proven nephritis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, March 2017 through December 201964% class III/IV nephritis
- Participants
- 222 patients
- Outcome
- Proportion of patients with abnormal kidney status at the most recent registry visit
- Follow-up
- Most recent registry visit
Methodological detailsmulticentre, registry-based, generalized linear mixed models
- Multicentre
- Registry-based
- Generalized linear mixed models
Main finding
As reported in the abstract
Abnormal kidney status at most recent registry visit (single-group result) · median (IQR) 17 (8-29) months from initial kidney biopsy
Patients with available data
55%
58 events
Observational data: associations, not effects.
Further findings
Medication use during induction
- Class IV nephritis more likely than class III to receive cyclophosphamide and rituximab during induction
Medication ever use across centres
- Substantial variation in mycophenolate, cyclophosphamide and rituximab ever use across rheumatology centres
Original publication
Childhood‐Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐Term Kidney Status and Variation in Care. Arthritis Care Res (Hoboken). Published 12 February 2023. doi:10.
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