Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles
Authors' conclusion
By integrating TWAS and mRNA expression profiles, genes, biological pathways, and environmental chemicals associated with JIA were identified.
Study context
- Population
- Published genome-wide association study (GWAS) data on juvenile idiopathic arthritis (JIA)
- Outcome
- Genes, pathways and environmental chemicals associated with JIA
Methodological detailsintegrative analysis with mRNA expression profiles, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, protein-protein interaction (PPI) network with Molecular Complex Detection (MCODE), chemical gene set enrichment analysis
- Integrative analysis with mRNA expression profiles
- GO and KEGG enrichment analyses
- PPI network with MCODE
- Chemical gene set enrichment analysis
Main finding
As reported in the abstract
- Genes associated with JIA identified by transcriptome-wide association study (TWAS)
- 1481
- Differentially expressed genes from mRNA expression profiles
- 154
- Overlapping genes (TWAS and mRNA expression profiles)
- 8
- Pathways from GO and KEGG enrichment of TWAS genes
- 163
- Clusters from PPI network and MCODE
- 8
- Environmental chemicals associated with JIA
- 287
Original publication
Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles. Arthritis Res Ther. Published 8 February 2023. doi:10.
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