Distinct expression profiles of inflammasome-associated genes in systemic juvenile idiopathic arthritis
Authors' conclusion
NLRC4, AIM2 inflammasome and CASP5 activation may play an important role in s-JIA. IRF1 may be associated with the development of MAS. The distinct expression profile of inflammasome-associated genes in s-JIA may indicate the heterogeneity of s-JIA.
Study context
- Population
- Patients with sJIA, including sJIA-associated macrophage activation syndrome (MAS), and healthy controls; whole blood sampled at diagnosis
- Participants
- 16 / 4 / 10
- Comparison
- sJIA vs healthy controls
- Systemic JIA (s-JIA)n = 16
- MASn = 4
- Healthy controls (HCs)n = 10reference
- Outcome
- mRNA expression of inflammasome-associated genes (Human Inflammasomes RT2 Profiler PCR Array)
- Follow-up
- Upon diagnosis with s-JIA or MAS
Methodological detailsgene expression profiling (polymerase chain reaction (PCR) array)
- Gene expression profiling (PCR array)
Main finding
As reported in the abstract
Inflammasome-associated gene mRNA expression
- Six genes (NLRC4, AIM2, CASP5, NAIP, TNFSF4, MAPK11) significantly elevated in s-JIA vs HCs
- IRF1 and NFKB1A significantly elevated in MAS vs s-JIA in the acute phase
- s-JIA expression clustered into two distinct groups: MYD88-dominant and NLRC5-dominant
- MYD88-dominant group had a significantly higher number of joints with active disease
Original publication
Distinct expression profiles of inflammasome-associated genes in systemic juvenile idiopathic arthritis. Rheumatology (Oxford). Published 30 October 2025. doi:10.
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