Clusters in paediatric Behçet’s disease: a multicentre international study
Authors' conclusion
Our study supports the notion that BD may tend to present in certain clusters in children as well.
Study context
- Population
- Patients with paediatric-onset Behçet's disease (BD) (<18 years) from Turkey, Iran and European countries (France and Italy), follow-up ≥6 months297 females, 49.5%
- Participants
- 600 patients
- Exposure
- Clinical manifestations across geographical regions: Turkey vs Europe vs Iran
- Turkeyn = 231
- Irann = 306
- Francen = 44
- Italyn = 19
- Outcome
- Clinical presentations (whole cohort)
Methodological detailscluster analysis
- Cluster analysis
Main finding
As reported in the abstract
- Mucocutaneous involvement
- 97.5%
- Ocular involvement
- 48.0%
- Musculoskeletal involvement
- 43.2%
- Neurological involvement
- 11.8%
- Vascular involvement
- 11.5%
- Gastrointestinal involvement
- 9.0%
- Cardiac involvement
- 2.0%
Observational data: associations, not effects.
Further findings
Regional differences in involvement
- Ocular involvement more prevalent in Iran vs other regions
- Gastrointestinal involvement more prevalent in Europe vs other regions
- Musculoskeletal and vascular involvement more prevalent in Turkey vs other regions
Original publication
Clusters in paediatric Behçet’s disease: a multicentre international study. RMD Open. Published 5 July 2025. doi:10.
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