Juvenile Psoriatic Arthritis Inception Cohort in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: Characteristics and Early Disease Outcomes
Authors' conclusion
In this inception cohort of JPsA in the CARRA registry, half of the patients had polyarticular presentation, and the majority required advanced therapy. Regardless of the treatment used, most patients had improvements in disease activity measures and PROs, with most achieving clinically inactive disease.
Study context
- Population
- Children with juvenile psoriatic arthritis (JPsA) diagnosed within 6 months of enrollment in the CARRA Registry62.4% female
- Participants
- 306 children
- Outcome
- Characteristics at CARRA registry enrollment and treatment patterns
- Follow-up
- Enrollment
Methodological detailsinception cohort, registry-based, follow-up up to 24 months
- Inception cohort
- Registry-based
- Follow-up up to 24 months
Main finding
As reported in the abstract
- Median age of onset, years (IQR 6.0-14.0)
- 11.0
- Polyarticular-course JPsA
- 52.3%
- Median active joint count (IQR 1.0-6.0)
- 3.0
- Enthesitis
- 20.1%
- Dactylitis
- 34.3%
- Active sacroiliitis
- 9.5%
- Psoriasis
- 58.8%
- TNFi use
- 61.1%
- Treated with ≥ 2 bDMARDs or traditional synthetic DMARDs
- 20.5%
Observational data: associations, not effects.
Further findings
- cJADAS-10 at baseline, median (IQR 5.5-15.0)
- 10.0
- cJADAS-10 at 24 months, median (IQR 0.0-5.0)
- 1.0
- Improvements also seen in active enthesitis and active sacroiliitis
Original publication
Juvenile Psoriatic Arthritis Inception Cohort in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: Characteristics and Early Disease Outcomes. J Rheumatol. Published 1 July 2025. doi:10.
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