Spondyloarthritis & psoriatic arthritis
Three-year follow-up of lumbar spine and sacroiliac magnetic resonance imaging changes in early axial spondyloarthritis with consideration of the lumbar facet joints
Authors' conclusion
Structural MRI changes in the SIJs and lumbar VUs, and radiographic axSpA progression, developed significantly within 3 years. MRI-detected lumbar FJI in early disease is associated with MRI signs of VU bone proliferation, indicating a risk of potential ossification.
Study context
- Population
- Newly diagnosed radiographic axial spondyloarthritis (axSpA) (modified New York and ASAS criteria), symptom duration < 5.5 years at baseline14 male, 10 female
- Participants
- 24 participants
- Exposure
- Baseline vs 3-year follow-up
- Outcome
- Radiographic and MRI changes in sacroiliac joints (SIJs) and lumbar spine, t0 to t1
- Follow-up
- 3 years
Methodological details3-year follow-up, Berlin magnetic resonance imaging (MRI) score extended by lumbar FJ inflammation score
- 3-year follow-up
- Berlin MRI score extended by lumbar FJ inflammation score
Main finding
As reported in the abstract
- Radiographic SIJ and syndesmophyte progression increased significantly between t0 and t1
- SIJ MRI: increasing BME, significant fat lesion progression, significant increases in sclerosis and erosion
- Lumbar spine: BME and fat lesions decreased; erosions in vertebral units (VUs) significantly increased
- FJ inflammation at t0 significantly influenced MRI changes in VU bone proliferation at t1
- Biologicals had no effect on MRI changes from t0 to t1
Observational data: associations, not effects.
Original publication
Three-year follow-up of lumbar spine and sacroiliac magnetic resonance imaging changes in early axial spondyloarthritis with consideration of the lumbar facet joints. Scand J Rheumatol. Published 29 October 2024. doi:10.
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