Spondyloarthritis & psoriatic arthritis
Baseline and 2-year differences in spinal symptoms and spinal and hip mobility in early axial spondyloarthritis and non-axial spondyloarthritis chronic back pain patients
Authors' conclusion
Over 2 years, all spinal symptoms and some mobility measures improved in both groups, but impairments remained prevalent (particularly in non-axSpA). Nevertheless, axSpA was associated with larger improvements in BP at night, mSchober, IMD and BASMI, but with more OWD impairment.
Study context
- Population
- Early axial spondyloarthritis (axSpA) and non-axSpA chronic back pain (BP) patients, SPACE cohort (mean symptom duration 13 months)
- Participants
- 294 vs 123
- Exposure
- Early axSpA vs non-axSpA chronic back pain
- axSpAn = 294
- non-axSpAn = 123reference
- Outcome
- 2-year spinal symptoms (overall BP, BP at night, morning stiffness intensity and duration) and spinal/hip mobility (OWD, cervical rotation, chest expansion, LSF, mSchober, IMD, BASMI)
- Follow-up
- 2 years
Methodological detailsSPondyloarthritis Caught Early cohort, linear or zero-inflated negative binomial regression adjusted for baseline value, sex, age and NSAID use
- SPondyloarthritis Caught Early cohort
- Linear or zero-inflated negative binomial regression adjusted for baseline value, sex, age and NSAID use
Main finding
As reported in the abstract
2-year outcomes, axSpA vs non-axSpA (multivariable)
axSpA vs non-axSpAOdds ratio (normal OWD) (95% CI)
Lower likelihood of normal OWD in axSpA
0.09(0.01–0.83)
- Larger improvement in axSpA
- β (BP at night) −0.85 (95% CI −1.47 to −0.23)
- Larger improvement in axSpA
- β (mSchober) 0.26 (95% CI 0.03–0.50)
- Larger improvement in axSpA
- β (intermalleolar distance (IMD)) 4.86 (95% CI 1.93–7.80)
- Larger improvement in axSpA
- β (Bath Ankylosing Spondylitis Metrology Index (BASMI)) −0.24 (95% CI −0.41 to −0.08)
Observational data: associations, not effects.
Further findings
Mean
| Outcome | axSpA | non-axSpA |
|---|---|---|
| BP at night (baseline) | 3.6 (SD 2.9) | 4.6 (SD 2.7) |
| OWD (baseline) | 0.5 (SD 1.2) | 0.1 (SD 0.7) |
BP at night (baseline)
- Non-axSpA had worse symptoms and mobility at baseline, except occiput-to-wall distance (OWD)
Original publication
Baseline and 2-year differences in spinal symptoms and spinal and hip mobility in early axial spondyloarthritis and non-axial spondyloarthritis chronic back pain patients. RMD Open. Published 26 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →