The role of the gastrointestinal microbiome on rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and reactive arthritis: A systematic review
Authors' conclusion
Existing cross-sectional studies suggest altered microbiome in disease states compared with controls.
Study context
- Population
- Studies of the microbiome of patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA) or reactive arthritis (ReA) compared with controls; literature up to August 202425,794 search results
- Comparison
- Gut microbiome of patients with RA, AS, PsA or ReA vs controls
- Outcome
- Alpha and beta diversity, abundance or depletion of organisms and functional analysis
Methodological detailsCochrane methods, PRISMA reporting, Newcastle-Ottawa Scale quality assessment
- Cochrane methods
- PRISMA reporting
- Newcastle-Ottawa Scale quality assessment
Pooled result
As reported in the abstract
Microbiome diversity
- Studies included: 53 RA, 34 AS, 6 PsA, 2 ReA
- Reduced diversity observed in disease groups and in patients with higher disease activity
Original publication
The role of the gastrointestinal microbiome on rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and reactive arthritis: A systematic review. Semin Arthritis Rheum. Published 31 October 2024. doi:10.
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