Prospective analysis on the gut microbiome and the risk of autoimmune rheumatic diseases in the population-based FINRISK 2002 cohort
Authors' conclusion
No evidence of association between baseline gut microbiome composition and the risk of incident ARDs (composite outcome) in the Finnish general adult population was detected in the current study.
Study context
- Population
- General adult population of the FINRISK 2002 cohort (Finland) who donated faecal samples in 2002
- Participants
- 6,242 participants
- Outcome
- Incident ARD (composite:
- RA
- AS or systemic connective tissue disorder) by alpha diversity
- Community composition
- Prevalent taxa
- Predicted pathways
Methodological detailspopulation-based, multivariable-adjusted models
- Population-based
- Multivariable-adjusted models
Main finding
As reported in the abstract
Incident ARD · median follow-up 19.8 years
Incident ARD
264
4.2%
Observational data: associations, not effects.
Original publication
Prospective analysis on the gut microbiome and the risk of autoimmune rheumatic diseases in the population-based FINRISK 2002 cohort. Rheumatology (Oxford). Published 16 July 2026. doi:10.
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