Autoimmune diseases exhibit shared alterations in the gut microbiota
Authors' conclusion
Our study highlights a strong link between autoimmune diseases and the gut microbiota, with notably consistent microbial alterations compared with that of other diseases
Study context
- Population
- Case-control datasets of 17 disease types34 case-control datasets
- Comparison
- Gut microbial alterations in autoimmune diseases vs other diseases
- Outcome
- Shared gut microbial alterations among different diseases
Methodological details16S rRNA sequencing data, DSS-induced colitis mouse model, collagen type II-induced arthritis mouse model
- 16S rRNA sequencing data
- DSS-induced colitis mouse model
- Collagen type II-induced arthritis mouse model
Pooled result
As reported in the abstract
Shared gut microbial alterations
- Microbial alterations among autoimmune diseases substantially more consistent than in other diseases (cancer, metabolic, nervous system disease)
- Microbial signatures showed notable discriminative power for disease prediction
- Autoimmune diseases: enrichment of Enterococcus, Veillonella, Streptococcus and Lactobacillus
- Autoimmune diseases: depletion of Ruminococcus, Gemmiger, Oscillibacter, Faecalibacterium, Lachnospiracea incertae sedis, Anaerostipes, Coprococcus, Alistipes, Roseburia, Bilophila, Barnesiella, Dorea, Ruminococcus2, Butyricicoccus, Phascolarctobacterium, Parabacteroides and Odoribacter, among others
Further pooled results
- L. salivarius showed protective roles in two separate inflammatory mouse models (DSS colitis, collagen-induced arthritis)
Original publication
Autoimmune diseases exhibit shared alterations in the gut microbiota. Rheumatology (Oxford). Published 19 July 2023. doi:10.
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