The natural history of end-stage knee osteoarthritis: Data from the osteoarthritis initiative
Authors' conclusion
Radiographic severity predisposed a knee to esKOA. However, worsening knee symptoms led to the development of incident esKOA.
Study context
- Population
- Knees of Osteoarthritis Initiative participants; natural history leading to end-stage knee OA (end-stage knee osteoarthritis (esKOA))7,691 knees
- Participants
- 4,165 participants
- Outcome
- Frequency of components of esKOA (knee symptoms, radiographic severity, limited mobility or instability) at the incident esKOA visit, the annual visit before, and interval change
Methodological detailssecondary analysis of Osteoarthritis Initiative data, knee-based analyses, descriptive statistics
- Secondary analysis of Osteoarthritis Initiative data
- Knee-based analyses
- Descriptive statistics
Main finding
As reported in the abstract
- Knees with moderate-to-severe radiographic OA at the visit before incident esKOA, original definition
- 62%
- Knees with moderate-to-severe radiographic OA at the visit before incident esKOA, alternate definition
- 50%
- Moderate-to-severe radiographic OA in knees with no esKOA, either definition
- <15%
- Knees reaching esKOA criteria based on increased knee symptom severity
- Over 80%
- Typically without worsening radiographic severity
- 80%
Observational data: associations, not effects.
Original publication
The natural history of end-stage knee osteoarthritis: Data from the osteoarthritis initiative. Semin Arthritis Rheum. Published 8 December 2022. doi:10.
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