Bone Marrow Lesions and Magnetic Resonance Imaging–Detected Structural Abnormalities in Patients With Midfoot Pain and Osteoarthritis: A Cross‐Sectional Study
Authors' conclusion
In individuals with persistent midfoot pain but no signs of OA on radiography, MRI findings suggested an underrecognized prevalence of OA, particularly in the second and third cuneiform-metatarsal joints, where BML patterns were consistent with previously recognized sites of elevated mechanical loading. Joint abnormalities were not strongly associated with pain or foot-related disability.
Study context
- Population
- Adults with symptomatic midfoot osteoarthritis (OA), persistent midfoot pain without radiographic OA, and asymptomatic controls
- Participants
- 107 adults
- Exposure
- Symptomatic midfoot OA vs persistent midfoot pain without radiographic OA vs asymptomatic controls
- Midfoot OAn = 50
- Midfoot painn = 22
- Controlsn = 35reference
- Outcome
- MRI-detected structural abnormalities (BMLs, subchondral cysts, osteophytes, JSN, effusion-synovitis, tenosynovitis, enthesopathy) and association with pain and foot-related disability (Manchester Foot Pain and Disability Index)
Methodological details3T Magnetic Resonance Imaging (MRI), Foot Osteoarthritis MRI Score
- 3T MRI
- Foot Osteoarthritis MRI Score
Main finding
As reported in the abstract
Severity sum score of midfoot BMLs
- Pattern of cuneiform-metatarsal joint involvement in midfoot pain similar to that in midfoot OA
- Midfoot pain vs Controls: P = 0.007
Observational data: associations, not effects.
Further findings
Univariable association of MRI features with pain
- BMLs, ρ (P < 0.01)
- 0.307
- JSN, ρ (P < 0.01)
- 0.423
- Subchondral cysts, ρ (P < 0.01)
- 0.302
- Univariable models
Multivariable association of MRI abnormalities with pain and disability
- Not associated when adjusted for covariates
- Multivariable models
Original publication
Bone Marrow Lesions and Magnetic Resonance Imaging–Detected Structural Abnormalities in Patients With Midfoot Pain and Osteoarthritis: A Cross‐Sectional Study. Arthritis Care Res (Hoboken). Published 2 December 2022. doi:10.
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