Lupus & antiphospholipid syndrome
The mediating effect of fatigue in impaired quality of life in systemic lupus erythematosus: mediation analysis of the French EQUAL cohort
Authors' conclusion
The effect of MSK flares and depression on physical health impairment is largely mediated by fatigue.
Study context
- Population
- Patients with SLE in a large multicentre French cohort (EQUAL)
- Participants
- 336 patients
- Outcome
- Proportion of the total effect of MSK flares and depression on physical health impairment (LupusQoL and SLEQOL domains) mediated by fatigue
Methodological detailsFrench EQUAL cohort, multicentre
- French EQUAL cohort
- Multicentre
Main finding
As reported in the abstract
Proportion of total effect on physical health impairment explained by fatigue
Musculoskeletal (MSK) flares, LupusQOL 'Physical health' domain
59.6% to 78%
MSK flares, SLEQOL 'Physical functioning' domain
51.1% to 73.7%
Depression, LupusQOL 'Physical health' domain
68.8% to 87.6%
Depression, SLEQOL 'Physical functioning' domain
79.3% to 103.2%
Observational data: associations, not effects.
Further findings
Prevalence of exposures at inclusion
- MSK flares, 94 patients
- 28%
- Depression, 99 patients
- 29.5%
Original publication
The mediating effect of fatigue in impaired quality of life in systemic lupus erythematosus: mediation analysis of the French EQUAL cohort. Rheumatology (Oxford). Published 19 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →