The effect of TNF treatment uptake on incident hospital admission in Western Australia
Authors' conclusion
Incident inpatient admission rates for JIA were stable over a 22-year period. The uptake of TNFi was not associated with lower admission rates for JIA, due mainly to an increase in admissions for joint injection.
Study context
- Population
- Patients <16 years hospitalised with juvenile idiopathic arthritis (JIA) in Western Australia, 1990–201259.2% girls, median age 8 years
- Participants
- 786 patients
- Outcome
- Incident hospitalisation for JIA
Methodological detailsjoin-point regression, hospital data
- Join-point regression
- Hospital data
Main finding
As reported in the abstract
Annual incident admission rate for JIA · 1990–2012
Annual incident admission rate per 100,000 person-years
7.9
95%CI 7.3, 8.4
Change 1990–2012, annual percentage change (APC) (95%CI: −0.3, 2.8), not significant
1.3
Observational data: associations, not effects.
Further findings
Annual hospital-based prevalence of JIA · 2012
- Prevalence per 1000
- 0.72
TNF inhibitor (TNFi) usage (defined daily doses (DDD)) · 2012
- Rose steadily from 2003; TNFi usage by children in 2012
- 1/2700
Overall admission rates
- APC, increased significantly
- 3.7 (95%CI: 2.3, 5.1)
Admission rates for joint injections
- APC, increased significantly
- 4.9% (95%CI: 3.8, 6.0)
Original publication
The effect of TNF treatment uptake on incident hospital admission in Western Australia. Pediatr Rheumatol Online J. Published 28 March 2023. doi:10.
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