The Combination of Depression and Obesity Is Associated With Increased Incidence of Subsequent Total Knee Arthroplasty
Authors' conclusion
The incidence of subsequent TKA was greatest for those with the combination of obesity and depression when compared to the Control group and those with individual diagnosis of obesity or depression.
Study context
- Population
- Individuals with knee OA (PearlDiver Mariner Ortho157 database)274,403 per cohort
- Participants
- 274,403 / 274,403 / 274,403 / 274,403
- Exposure
- Depression+Obesity vs Control, Obesity and Depression
- Controln = 274,403reference
- Obesityn = 274,403
- Depressionn = 274,403
- Depression+Obesityn = 274,403
- Outcome
- Incidence of subsequent total knee arthroplasty (TKA) within the first 5 years after index OA diagnosis
- Follow-up
- 5 years
Methodological detailsmatched by age, sex and Charlson Comorbidity Index, PearlDiver Mariner Ortho157 database
- Matched by age, sex and Charlson Comorbidity Index
- PearlDiver Mariner Ortho157 database
Main finding
As reported in the abstract
Incidence of TKA
Relative risk (95% CI)P value
Depression+Obesityvs Control
1.43(1.41,1.45)
P < 0.0001Depression+Obesityvs Obesity
1.13(1.11,1.14)
P < 0.0001Depression+Obesityvs Depression
1.53(1.50,1.55)
P < 0.0001Observational data: associations, not effects.
Original publication
The Combination of Depression and Obesity Is Associated With Increased Incidence of Subsequent Total Knee Arthroplasty. J Rheumatol. Published 15 September 2023. doi:10.
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