Lupus & antiphospholipid syndrome
The causal effects of age at menarche, age at first live birth, and estradiol levels on systemic lupus erythematosus: A two-sample Mendelian randomization analysis
Authors' conclusion
Our findings revealed that AAM may be associated with increased risk of the development of SLE, while there were no such causal effects from AFB and estradiol levels.
Study context
- Population
- GWAS dataset related to systemic lupus erythematosus (SLE) (outcome) and open access databases for age at menarche (AAM), AFB and estradiol levels (exposures)
- Outcome
- Causal effect of age at menarche, age at first live birth and estradiol levels on SLE
Methodological detailsGWAS summary data
- GWAS summary data
Main finding
As reported in the abstract
SLE, causal effect of exposures (MR)
- AAM, Mendelian randomization (MR) Egger: beta (SE 0.948), p = 0.909
- 0.116
- AAM, weighted median: beta (SE 0.192), p = 0.030
- −0.416
- AAM, IVW: beta (SE 0.165), p = 0.016
- −0.395
- AFB, MR Egger: beta (SE 1.469), p = 0.065
- - 2.815
- AFB, weighted median: beta (SE 0.378), p = 0.377
- 0.334
- AFB, IVW: beta (SE 0.282), p = 0.505
- 0.188
- Estradiol levels, MR Egger: beta (SE 0.294), p = 0.651
- 0.139
- Estradiol levels, weighted median: beta (SE 0.108), p = 0.559
- 0.063
- Estradiol levels, IVW: beta (SE 0.097), p = 0.192
- 0.126
Original publication
The causal effects of age at menarche, age at first live birth, and estradiol levels on systemic lupus erythematosus: A two-sample Mendelian randomization analysis. Lupus. Published 29 May 2023. doi:10.
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