Lupus & antiphospholipid syndrome
Causal relationship between systemic lupus erythematosus and primary liver cirrhosis based on two-sample bidirectional Mendelian randomization and transcriptome overlap analysis
Authors' conclusion
The two-sample bidirectional MR analysis revealed that SLE and PBC were high-risk factors for each other, indicating that they had similar genetic bases, which could to some extent overcome the limitation of insufficient overlap in case samples of SLE and PBC.
Study context
- Exposure
- Systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) as genetic exposures for each other
- Outcome
- Potential causal relationship between SLE and PBC
Methodological detailsCochran's Q-test for heterogeneity, sensitivity test, Gene Expression Omnibus database, machine learning
- Cochran's Q-test for heterogeneity
- Sensitivity test
- Gene Expression Omnibus database
- Machine learning
Main finding
As reported in the abstract
- SLE and PBC were both high-risk factors for the occurrence and development of the other
- Mendelian randomization (MR) analysis had heterogeneity but was robust
Observational data: associations, not effects.
Further findings
Transcriptome overlap hub genes
- Hub genes identified
- 9
- Machine learning verified high recognition efficiency for SLE patients
Hub gene SOCS3 (MR validation)
- No potential causal relationship between SOCS3 and SLE
- SOCS3 a high-risk factor for potential risk of PBC
Original publication
Causal relationship between systemic lupus erythematosus and primary liver cirrhosis based on two-sample bidirectional Mendelian randomization and transcriptome overlap analysis. Arthritis Res Ther. Published 2 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →