Lupus & antiphospholipid syndrome
Peripheral mononuclear cells and systemic lupus erythematosus association: Integrated study of single-cell sequencing and mendelian randomization analysis
Authors' conclusion
This study demonstrates the potential of scRNA-seq and MR in identifying critical factors in SLE pathogenesis, thereby supporting the need for targeted therapies.
Study context
- Population
- Patients with Systemic Lupus Erythematosus (SLE) (GSE135,779 dataset; IEU Open GWAS project data)
- Outcome
- Genes causally related to SLE (MR analysis of eQTLs of single-cell marker genes)
Methodological detailssingle-cell RNA sequencing, Mendelian randomization
- Single-cell RNA sequencing
- Mendelian randomization
Main finding
As reported in the abstract
- Genes causally related to SLE by Mendelian randomization (MR), particularly IFIT3
- 12
Original publication
Peripheral mononuclear cells and systemic lupus erythematosus association: Integrated study of single-cell sequencing and mendelian randomization analysis. Lupus. Published 15 October 2024. doi:10.
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