The association of serum uric acid with all-cause and cardiovascular mortality among adults with rheumatoid arthritis: a cohort study
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.53 95% CI 1.10–2.14Authors' conclusion
The results of the present study demonstrated that high SUA levels were significantly associated with increased risks of all-cause and CVD-associated mortality in patients with RA.
Study context
- Population
- Adults with rheumatoid arthritis (RA), National Health and Nutrition Examination Survey 2001–2018; mortality from national death records through 31 December 2019
- Participants
- 2,312 adults19,133 person-years
- Exposure
- Highest vs lowest serum uric acid (SUA) quartile
- Outcome
- All-cause and CVD-associated mortality
Methodological detailsNHANES 2001–2018, weighted survival curves, Cox proportional hazards regression, restricted cubic splines, stratified analyses
- NHANES 2001–2018
- Weighted survival curves
- Cox proportional hazards regression
- Restricted cubic splines
- Stratified analyses
Main finding
All-cause mortality
Hazard ratio
1.53
95% CI 1.10–2.14
Highest SUA quartilevs Lowest SUA quartile
HR 1.53 (95% CI 1.10–2.14)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD-associated mortalityFully adjusted model | 1.93 (1.14–3.27) | |
| 0.20.5125Hazard ratio (log scale) |
Cardiovascular disease (CVD)-associated mortality
- 198 CVD-associated deaths recorded
- U-shaped association between SUA and CVD-associated mortality (restricted cubic splines (RCS))
Original publication
The association of serum uric acid with all-cause and cardiovascular mortality among adults with rheumatoid arthritis: a cohort study. Clin Exp Rheumatol. Published 21 May 2023. doi:10.
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