Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case–control study
Authors' conclusion
Mitochondrial content and function were not associated with insulin sensitivity among participants with RA. However, our study demonstrates a significant association between muscle mitochondrial content and physical activity level
Study context
- Population
- Patients with rheumatoid arthritis (RA) and controls
- Exposure
- RA vs controls
- Outcome
- Association of muscle mitochondrial content and oxidative phosphorylation with insulin resistance (Matsuda index)
Methodological detailscase–control, prospective
- Case–control
- Prospective
Main finding
As reported in the abstract
Insulin sensitivity (Matsuda index)
RA
3.95
median · IQR 2.33–5.64
Controls
7.17
median · IQR 5.83–7.75
P = 0.02
Observational data: associations, not effects.
Further findings
Muscle mitochondrial content (CS activity)
P = 0.03
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| OxPhos normalized to mitochondrial content | 0.14 (0.02–0.26) | P = 0.03 | |
| −0.200.20.4Difference (linear scale) |
Among RA: correlations of muscle citrate synthase (CS) activity
- CS activity vs Matsuda index, ρ
- - 0.05, p = 0.84
- CS activity vs IPAQ total MET-minutes/week, ρ
- 0.44, p = 0.03
- CS activity vs Actigraph-measured physical activity time (MET rate), ρ
- 0.47, p = 0.03
Original publication
Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case–control study. Arthritis Res Ther. Published 20 May 2023. doi:10.
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