Association between sleep disorders and rheumatoid arthritis in U.S. adults
Main finding · Odds of RA, fully adjusted modelResult — go to the resultOdds ratio 1.76 95% CI 1.46–2.13Authors' conclusion
In conclusion, our findings indicate a statistically significant association between sleep disorders and the prevalence of RA in U.S. adults.
Study context
- Population
- U.S. adults aged ≥ 18 years, National Health and Nutrition Examination Survey (NHANES) 2005–20181,589 (4.28%) with rheumatoid arthritis (RA)
- Participants
- 28,040 adults
- Exposure
- Sleep disorders vs no sleep disorders
- Sleep disordersn = 4,168
- Outcome
- RA
Methodological detailsweighted multivariate logistic regression, three models: unadjusted, minimally adjusted, fully adjusted, subgroup and sensitivity analyses
- Weighted multivariate logistic regression
- Three models: unadjusted, minimally adjusted, fully adjusted
- Subgroup and sensitivity analyses
Main finding
Odds of RA, fully adjusted model
Odds ratio
1.76
95% CI 1.46–2.13
P < 0.001
Sleep disordersvs No sleep disorders
OR 1.76 (95% CI 1.46–2.13); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Subgroup analyses
- Positive association persisted across all examined strata, with no significant interactions
- P for interaction > 0.05
Original publication
Association between sleep disorders and rheumatoid arthritis in U.S. adults. Arthritis Res Ther. Published 7 December 2025. doi:10.
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