The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018
Authors' conclusion
In general, there is a positive correlation between SII and rheumatoid arthritis.
Study context
- Population
- US adults, NHANES 1999–2018; Rheumatoid arthritis (RA) derived from questionnaire data2,642 (7.03%) with RA
- Participants
- 37,604 adults
- Exposure
- Higher vs lower SII
- Outcome
- Association between SII and RA
Methodological detailsweighted multivariate regression, subgroup analysis, restricted cubic splines
- Weighted multivariate regression
- Subgroup analysis
- Restricted cubic splines
Main finding
As reported in the abstract
RA, per ln-SII
High ln-SII associated with increased likelihood of RA
fully adjusted OR 1.167
95% CI 1.025–1.328P=0.020
Observational data: associations, not effects.
Further findings
Interaction (subgroup) tests
- No significant effect on the association
Dose-response (restricted cubic spline)
- Non-linear relationship between ln-SII and RA; cutoff value of SII for RA
- 578.25
- Risk of RA increases rapidly when SII exceeds the cutoff
Original publication
The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018. Arthritis Res Ther. Published 4 March 2023. doi:10.
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